• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The straw includes a tube (11) and a plug (12) fixed to the tube (11) and having a male connector (29) configured for a syringe needle (44) having a syringe tip female connector (45) with a standard frustoconical internal surface can be connected to said plug (12) by engaging the needle connector (45) of the needle on the male connector (29) of the plug (12). The injection device comprises such a straw (10) and a syringe needle (44). The method of emptying the straw comprises the step of pushing the dose of liquid substance (21) packaged in the straw (10) to the plug (12).
    公开号:FR3036954A1
    申请号:FR1555026
    申请日:2015-06-03
    公开日:2016-12-09
    发明作者:Kappel-Dufour Anne Linda Van；Jean-Charles Gorges；Eric Schmitt
    申请人:IMV Technologies SA；
    IPC主号:
    专利说明:

    [0001] The invention relates generally to the preservation of a predetermined dose of liquid-based substance, and more particularly to flakes for effecting such preservation. It is known that such straw comprises a tube and a plug disposed in the tube. The plug is usually of the tripartite type originally described in French Patent 995,878, corresponding to British Patent 669,265, that is to say formed by two buffers of fibrous substance enclosing a powder that is converted on contact with a liquid in the form of an impermeable paste or gel adhering to the wall of the tube so that the cap is liquid-tight. Similar but improved stoppers are described by French Patent Applications 2,824,255 and 2,824,256, corresponding to US Patent Applications 2002/0183653 and 2002/0188222. There are also known plugs of another type, for example a plug comprising or associated with an insert described by the French patent application 2,771,284 corresponding to the US Pat. No. 6,300,125, by the French patent application 2,771,285 corresponding to the United States Patent Application 2001/0014376, French Patent Application 2,784,572 corresponding to US Patent 6,416,611 and French Patent Application No. 2,932,064; or a plug made of a monobloc cylinder of hydrophobic microporous material described by European Patent Application 0 873 726; or finally a plug made of a monoblock cylinder of self-sealing sintered microporous material described by PCT application WO 2010/070533. In the initial state, the stopper is disposed in the vicinity of one of the ends of the tube and it is provided that in the filled state, the dose of liquid substance that must be stored in the straw is disposed between the stopper. and the other end of the tube (end farthest from the plug). To fill the straw, the end closest to the plug is placed in communication with a source of vacuum while the end farthest from the plug is placed in communication with a container containing the substance to be introduced into the straw. The air initially contained between the plug and the end of the tube furthest from the plug is sucked through the plug as the substance progresses through the tube until it meets the plug. If necessary, after filling, the straw is welded in the vicinity of one or both ends and is stored cold. The flake 10 and in particular the material of the tube are provided so that cold storage can be performed by immersing the flake in a liquid cryogenic agent such as liquid nitrogen. To empty the flake, if necessary after cutting the welded end portions and defrosting, is introduced into the tube through the end nearest the plug a rod that bears against the plug. With this rod, the plug is slid in the manner of a piston towards the end farthest from the plug, which causes the expulsion of the dose of substance that had been introduced into the straw. When the straw is used to store diluted animal semen, in particular bovine semen, emptying the straw is used to perform artificial insemination. The invention aims to provide such a straw that offers operators new capabilities while remaining simple, convenient and economical to manufacture and use.
    [0002] The invention proposes for this purpose a straw for the preservation of a predetermined dose of liquid-based substance, comprising a tube extending between a first end and a second end and comprising a liquid-tight plug disposed in the tube in the vicinity. its first end and extending between a first end facing the first end of the tube and a second end facing the second end of the tube, characterized in that said plug: - is fixed vis-à-vis the tube; 3 - comprises a male connector end extending between a first end facing the first end of the tube and a second end facing the second end of the tube, having a normalized frustoconical outer surface increasing in diameter of the first end of the tube. the nozzle towards the second end of the nozzle, configured so that a syringe needle having a female socket with a standard frustoconical internal surface can be connected to said plug by engaging the needle connection tip of the needle on the male connection end cap with the inner frustoconical surface of the female tip 10 in contact with the outer frustoconical surface of the male end; and has an inner duct extending between the first end of the nozzle and the second end of the plug. The inner conduit of the syringe needle can thus be brought into communication, via the inner conduit of the stopper, with the internal space to the tube located between the second end of the stopper and the second end of the tube. This internal space in the tube is intended, as in conventional flakes, to receive the predetermined dose of liquid-based substance.
    [0003] If a syringe needle (eg, an injection needle) is connected to the tip of the stopper and the dose of substance contained in the straw is drawn to the stopper, for example as explained herein. afterwards, the substance will pass through the internal duct of the stopper and then the internal duct of the needle and may be expelled at the distal end of the needle, that is to say the pointed end situated on the side opposite the needle end of the needle. It will be observed that contrary to conventional flakes, the cap is not displaced to push the dose of substance towards the second end of the tube but that the stopper is fixed and that it is the dose of substance that is pushed towards the stopper and therefore towards the first end of the tube.
    [0004] The flake according to the invention can thus play not only the role of a substance conditioning element of the substance for its preservation, including cryogenic temperatures (traditional role for a straw), but also the role of a syringe body to which a syringe needle can be directly connected and whose contents can be ejected through the distal end of this needle. Thus, for liquid-based substances which, after a period of storage, including at cryogenic temperatures, must be injected with a needle for example into a bag containing a diluting liquid, the straw according to the invention makes it possible to avoid that the dose of substance must be transferred from the conditioning unit that it constitutes to a syringe body. This offers the advantage of simplifying the task of the operator and saving the supply of the syringe body.
    [0005] In addition, the handling of the liquid-based substance is reduced, which in some cases is favorable for the preservation of its properties, in particular if the substance contains constituents sensitive to the mechanical stresses occurring when passing through a narrow duct. like the inner duct of an injection needle. Such a substance is for example a vaccine comprising cells sensitive to mechanical stresses. The flake according to the invention makes it possible to benefit from the conditioning qualities of the liquid-based substances offered by the flakes, from the compatibility with the existing cold storage devices of the flakes, including at cryogenic temperatures, for example the conventional holding cups. flakes in liquid nitrogen, while providing the capabilities of a syringe body; and this simply by implementing in a thin tube of flake a cap configured accordingly. According to advantageous features, in an initial state before use, the first end of the plug is located in the tube at a predetermined distance from the first end of the tube for welding the tube between the first end of the plug and the first end of the tube. .
    [0006] When the flake is closed by welding at its ends and immersed in the cryogenic agent such as liquid nitrogen, the tip and more generally the cap is isolated from the liquid cryogen by the tube of the straw and therefore protected from cross-contamination likely to be conveyed by the liquid cryogen. It will be observed that if the tip was disposed out of the projecting tube beyond the first end of the tube, the straw according to the invention would have a larger capacity but could not offer such an insulation capacity of the nozzle .
    [0007] According to advantageous characteristics, in an initial state before use, the plug comprises at its first end a cap to be removed closing off said inner conduit of the cap. This seal is of course to be removed before emptying the straw. The presence of the lid until the flask emptying operation ensures that there is no substance that passes into cap before emptying. In particular, there is no substance lost in the portion of the straw between the cap and the first end of the tube. According to advantageous features, an annular wall is disposed between the cap and the spigot, the inner conduit of the cap extending beyond the first end of the spigot in the annular wall to the operculum which closes, the outer surface of the annular wall being recessed vis-à-vis the outer surface of the male end. The lid is removed by cutting or even tearing the annular wall.
    [0008] The remaining annular wall piece does not interfere with the engagement of the socket as the outer surface of the annular wall is recessed with respect to the outer surface of the socket. According to advantageous features, the cap comprises a body attached to the tube and an appendage protruding from said body attached to the tube 30 only through the body, which appendix comprises said male end and extends to the first end of the cap.
    [0009] Thus, the plug can be effectively secured to the tube by the body while the tube leaves free the outer surface of the tip. In addition, if necessary, the tube can be removed around the appendix after being cut. According to advantageous features, the plug body and the tube are secured independently of plug contact with said liquid-based substance. In other words, the degree of securing between the tube and the plug is the same without prior contact and after contact of the plug with the liquid-based substance. Thus, unlike conventional flake caps, there is no adhesion of a sealant to the tube once the plug has been moistened. It is possible to fill the straw otherwise than by suctioning the air through the stopper through the first end of the tube, for example by means of a needle which is inserted into the tube at its second end until the tip of the needle is close to the cap then the substance is injected into the tube at the same time as the needle back. The subjection of the stopper to the tube being independent of the contact with the liquid substance, no precautions are to be taken with the straw according to the invention to ensure that the liquid substance has come into contact with the stopper. It is also possible to voluntarily leave the liquid substance away from the cap, for example to have a useful air bubble during freezing. According to advantageous features: the body is rigid at least at the periphery and has an external surface having non-return projections oriented to enable the plug to be slid vis-a-vis the tube from the first end to the second end and to resist sliding of the plug vis-à-vis the tube to the first end of the tube; the body is rigid at least peripherally and has an outer surface having at least one annular rib having a straight surface facing the first end of the tube and an inclined surface facing the second end of the tube, the inclined surface being inclined inwards and towards the second end of the tube; - The body is rigid at least peripherally and has an outer surface having at least two annular ribs away from one another; The body has on its external surface an annular groove near the appendix; said male connection piece is a male luer tip; said stopper is made entirely of impervious material to gases and liquids independently of a contact of the stopper with said liquid-based substance; and / or - said plug is entirely made of rigid plastic material molded in one piece. The invention also aims, in a second aspect, a device for injecting a liquid-based substance comprising a straw as explained above and a syringe needle having a female connection endpiece with a frustoconical inner surface engaged. on the male connection end cap of said straw. The invention also aims, in a third aspect, a method of emptying a straw as explained above, comprising a dose of liquid-based substance disposed between the second end of the plug and the second end of the tube, having the step of pushing the dose of liquid-based substance to the first end of the tube after connecting the tip of a syringe needle to the male end of the plug.
    [0010] According to advantageous features: the step of pushing the dose of liquid-based substance is carried out with the second end of the tube which remains closed while the tube is crushed progressively from the second end of the tube towards the stopper ; or the step of pushing the dose of liquid-based substance is carried out with the second end of the tube which is open, thanks to a piston introduced by this end which is moved towards the stopper.
    [0011] The description of the invention will now be continued by the description of exemplary embodiments, given below by way of illustration and without limitation, with reference to the appended drawings, in which: FIG. 1 is a diagrammatic view of FIG. a flake according to the invention, in the initial state before use where it is empty and open at both ends; - Figures 2 and 3 are respectively a side view and a sectional view of the plug of this straw, shown separately; FIG. 4 is a sectional view of the end of the straw which is shown on the left in FIG. 1, except that a syringe needle has been connected to the stopper of this straw after The lid of its cap was cut and removed and its tube was cut at the same location and the cut end portion of the tube removed; Figure 5 is a view similar to Figure 1 but with the straw in the filled state; - Figure 6 is a view similar to Figure 5 but with the tube of the straw welded at both ends; FIG. 7 is a view similar to FIG. 6 but after the lid of the straw cap has been cut out and then removed and its tube cut at the same place and then the cut end portion of the tube removed; FIG. 8 is a view similar to FIG. 7 except that a syringe needle has been connected to the stopper of the straw; FIG. 9 is a view similar to FIG. 8 but in elevation rather than in plan and further showing the rolls of a flail emptying device by progressive crushing of the tube along it from the end of the tube furthest from the stopper; FIG. 10 is a view similar to FIG. 7 but with the other side of the tube which has also been cut and the end portion thus cut off which has been removed while a syringe needle has been connected to the stopper. straw; Figure 11 is a view similar to Figure 10 but further showing the plunger of a plunger emptying device by sliding the plunger in the tube from the farthest end of the stopper; - Figure 12 shows a pair of curved blade scissors 5 for cutting the straw tube at the body of the plug; - Figure 13 is a view similar to Figure 7 but with the cut tube at the body of the cap; - Figures 14 to 16 are views similar to Figures 1 to 3, but for a variant of the straw of smaller capacity; Figure 17 is a view similar to Figure 8 but for this variant of the straw while the tube is cut at the plug body; and - Figures 18 and 19 are views similar to Figure 15 but for variants of the plug where the body is shaped differently.
    [0012] The straw 10 illustrated in FIG. 1 in the initial state (before use) comprises a tube 11 and a plug 12. The tube 11 is made of extruded plastic with an internal diameter which is thus calibrated. Here, this internal diameter is of the order of 8.20 mm and the length of the tube 11 is of the order of 130 mm.
    [0013] The tube 11 extends between one end 16 (which is seen on the left in FIG. 1) and one end 17 (which is seen on the right in FIG. 1). The material of the tube 11 is here Surlyn®, which has good weldability properties and excellent compatibility with cryogenic temperatures. For more details, reference may be made to French patent application 2,651,793 to which US Pat. No. 5,190,880 corresponds. Alternatively, the tube material is in another heat-shrinkable plastic material and resistant to cryogenic temperatures, for example PVC, TPE or PP. The plug 12 is made of a material which has the same impermeability properties to gases and liquids without and with prior contact of the plug with a liquid, in particular an aqueous liquid.
    [0014] In particular, unlike conventional flake closures, the plug 12 does not include dry powder sealant which becomes a paste or gel once moistened. The material of the plug 12 is polyethylene, more specifically HDPE. Alternatively, the plug 12 is in another relatively rigid thermoplastic material, for example polypropylene (PP). The plug 12 is disposed in the tube 11 near its end 16. The plug 12 extends between an end 19 facing the end 16 of the tube 11 and an end 18 facing the end 17 of the tube 11 In the initial state (before use) of the straw 10, illustrated in FIG. 1, the end 19 of the plug 12 is located in the tube 11 at a distance from the end 16 of the tube 11. This distance has It has been predetermined that it is large enough to make it possible to weld the tube 11 close to the end 16, as shown in FIG. 6. In general, the plug 12 has an axisymmetric configuration and it is positioned coaxially with the tube 11. The plug 12 has a body 9 and an appendix 63 projecting from the body 9 and extending to the end 19. The appendix 63 comprises a male endpiece 29, a cover 33 located at the end 19 and an annular wall 64 connecting the opercul The body 9 is directly attached to the tube 11. The projection 63 protruding from the body 9 is secured to the tube 11 only via the body 9. Thus, the tube 11 leaves free the outer surface of the appendix 63, in particular the outer surface 14 of the spigot 29. As explained in more detail later, the outer surface 14 is frustoconical normalized to cooperate with the normalized frustoconical inner surface 46 of the spigot. female tip 45 of a syringe needle 44 (Figure 4).
    [0015] In addition, if necessary, the portion of the tube 11 surrounding the appendix 63 can be cut out and removed, as shown in FIG. 13. In the filled state of the straw 10 (FIG. 5), the dose of substance The liquid base 21 which must be stored in the straw 10 is disposed between the plug 12 and the end 17 of the tube 11 farthest from the plug 12. The straw 10 here has a useful capacity of about 4 ml. The implementation of the filling operation will be explained later. If necessary, after filling, the tube 11 of the straw is welded in the vicinity of one or both of its ends 16 and 17 (FIG. 6) and is stored in the cold. The implementation of emptying the flake 10, optionally after thawing and cutting of one or both welded end portions, will be explained later.
    [0016] Of course, if the tube 11 has been welded at one end and the welded portion has subsequently been cut and removed, the tube 11 then has a new end set back from the initial end. Similarly, if the tube 11 has been cut to remove an end portion initially located around the appendix 63, the tube 11 then has a new end recessed 20 with respect to the initial end. For simplicity, in the following will also use the reference numerals 16 and 17 for the new ends of the tube 11 each recessed relative to the respective initial end. During manufacture of the straw 10, the plug 12 is placed in the tube 11 by simple insertion through the first end 16 of the tube 11 and forced sliding towards the second end 17 of the tube 11 until reaching the provided for the plug 12 in the tube 11. The fact that the plug 12 can slide in the tube 11 only if a large force is exerted (forced nature of this sliding) makes it possible to provide a holding in place of the plug 12 in the tube 11 is sufficient to take up the forces exerted when connecting a syringe needle 44 (FIG. 4) by engaging the female connection piece 45 of the needle 44 on the male connection piece 29 of the plug 12 with the internal frustoconical surface 3036954 12 of the socket 45 in contact with the outer frustoconical surface 14 of the spigot 29. As explained below, the plug 12 is configured to resist sliding towards the first end. This allows the plug 12 to take up the great efforts exerted on the end 18 of the plug 12 by the substance 21 during the emptying (FIGS. 9 and 11) and, where appropriate, during the freezing where it an increase in volume of the substance 21 which urges the plug 12 towards the end 16 of the tube 11. The male end 29 extends between an end 60 turned towards the end 16 of the tube 11 and a turned end 61. towards the end 17 of the tube 11. The frustoconical outer surface 14 of the male end 29 increases in diameter from the end 60 of the endpiece 29 towards the end 61 of the endpiece 29. Here, the taper of the outer surface 14 of the spigot 29 is Luer-sized, defined by ISO 594-1: 1986 or by DIN and EN 1707: 1996 and 20594-1: 1993. An inner conduit 20 is formed in the plug 12. The inner conduit 20 extends between the end 60 of the male end 29 and the end 18 of the plug 12.
    [0017] The inner conduit 20 thus passes through the male end 29 and the body 9 opening into the internal space of the tube 11 intended to be filled by the substance 21. The inner conduit 20 extends beyond the end 60 of the male end 29 in the annular wall 64 to the lid 33 which closes it.
    [0018] The lid 33 is here formed by a straight wall oriented transversely to the inner conduit 20. The lid 33 is to be removed before connecting the needle 44 and emptying the straw. The inner conduit 20 decreases in diameter from the end 18 of the plug 12 to the end 60 of the spigot 29, with three successive frustoconical portions stepped.
    [0019] The outer surface of the annular wall 64 is recessed vis-à-vis the outer surface 14 of the spigot 29. The cap 33 is removed by cutting or tearing the annular wall 64.
    [0020] The remaining annular wall piece 64 does not interfere with engagement of the socket 45 since the outer surface of the annular wall 64 is recessed from the outer surface 14 of the socket 29 (see FIG. ). Note that the thickness of the annular wall 64 is smaller than that of the spigot 29, which facilitates the cutting of the annular wall 64 to remove the lid 33. The body 9 will now be described in detail. 2 and 3. The body 9 extends between an end protruding from the appendix 63 (end facing the end 16 of the tube 11) and the end 18 of the plug 12. The body 9 comprises a plurality of annular ribs 22, here two identical ribs, formed on its outer surface 28. The ribs 22 are arranged at a distance from each other, with a predetermined distance between them. This gap makes it possible to stabilize the plug 12 in the tube 11. Each annular rib 22 has a straight surface 24 facing the end 16 of the tube 11 and an inclined surface 25 facing the end 17 of the tube 11.
    [0021] The surface 25 is inclined inwardly and towards the end 17 of the tube 11. For each rib 22, the straight surface 24 and the inclined surface 25 meet at an edge 65. These annular ribs 22, and shaped, provide a non-return effect allowing the forced sliding of the plug 12 vis-à-vis the tube 11 of the end 16 towards the end 17 and resistant to sliding of the plug 12 vis-à-vis the tube 11 to the end 16 of the tube 11.
    [0022] The material in which the plug 12 is made is relatively rigid and therefore the periphery of the body 9 is relatively rigid, and in any case more than the wall of the tube 11 which is relatively thin. It will be observed that the general diameter of the outer surface 28 of the body 9 (diameter of the surface 28 with the exception of the annular ribs 22 and the annular groove 30 whose interest will be explained hereinafter) corresponds to the internal diameter of the tube 11. The inclined surfaces 25 form ramps for deforming the wall of the tube 11 to allow the forced sliding of the plug 12 to the end 17 of the tube 11. The straight surfaces 24 form stops to allow the plug 12 to resist The body 9 also has, at the end 18 of the plug 12, a chamfered edge forming a guiding surface 23 inclined towards the inside and towards the end 18 of the plug 12. The annular groove 30 is formed on the outer surface 28 near the appendix 63. More specifically, the annular groove 30 is formed between the appendix 63 and the annular rib 22 closest.
    [0023] The annular groove 30 has a concave curved bottom surface. The annular groove 30 is useful for guiding the cutting of the tube 11, for example with the pair of curved blade scissors 53 illustrated in FIG. 12.
    [0024] We will now describe in more detail the needle 44 in support of FIG. 4. The female end piece 45 extends between an end 55 that is seen on the left in FIG. 4 and an end 56 that we see on the right. The female end 45 has a flange 48 at its end 56.
    [0025] The needle 44 further includes a hollow stem 39 projecting from the socket 45 from its first end 55.
    [0026] The inner channel 40 of the needle 44 extends from the end 56 of the socket 45 to the tip of the hollow stem 39. The hollow stem 39 here has a known diameter as a gauge 18 or gauge. 20. The needle 44 is of the hypodermic type.
    [0027] In order to engage the socket 45 on the spigot 29, the annular wall 64 of the appendix 63 has been cut out and the lid 33 removed. The tube 11 was cut at the same location and the cut end portion of the tube 11 removed. When the female end piece 45 is engaged on the male endpiece 29, the frustoconical inner surface 46 of the female endpiece 45 is in contact and matches the frustoconical external surface 14 of the male endpiece 29. The internal conduit 20 of the male end 29 opens into the internal channel 40 of the needle 44. The straw 10 to which is connected the needle 44 with its endpiece 15 female connection 45 with a frustoconical inner surface 46 engaged on the male connector end 29 of the plug 12 forms a device for injecting a fluid substance whose operation is explained below. We will now describe the use of the flake 1 in support of Figures 5 to 13.
    [0028] The straw 10 illustrated in FIG. 5 comprises a predetermined dose of liquid-based substance 21, here a concentrated vaccine solution. The filling of the straw 10 is carried out using a needle (not shown), connected to a reservoir (not shown) of substance 21, which is inserted into the tube 11 by the end 17 of the tube 11 until its end comes close to the plug 12. During the injection of the substance 21, the needle is gradually retracted. Note that here the substance 21 does not penetrate, or extremely little, inside the inner conduit 20 of the plug 12. After filling, the inner conduit 20 therefore contains a certain volume of air.
    [0029] It will also be noted that the volume of the predetermined dose injected is such that there remains a portion of the tube 11 that is not filled with the substance 21 on the side of the end 17. The tube 11 is then welded near its two ends. 5 and 17. In the vicinity of each end, a weld 41 is made using two heating jaws (not shown) between which is crushed by pinching an end portion of the tube 11. The portion thus crushed takes a position flattened by forming two lips 42 (FIG. 9) in contact with each other. Simultaneously with the crushing, the heat transmitted by the heating jaws to the material of the tube 11 (in this case Surlyn®) causes the formation of the hermetic seal 41 between the two lips 42. The straw 10 with the tube 11 welded in the vicinity of its two ends 16 and 17 is illustrated in FIG.
    [0030] It will be appreciated that, since a portion of the unfilled tube 11 remains with the substance 21, an air bubble 43 of a predetermined volume is trapped in the tube 11 between the weld 41 in the vicinity of the end. 17 and the dose of substance 21. This air bubble 43 is useful during the freezing of the straw to allow the volume increase of the substance 21. We will now describe a first embodiment of emptying the flake 10 in order to empty the straw 10, the tube 11 is first cut between its end 16 and the body 9 of the stopper 12 and then the end portion 25 of the tube 11 which has been removed is removed. been cut. The annular wall 64 of the appendix 63 is then cut and the cover 33 removed. It is possible to cut at the same time the tube 11 and the annular wall 64, for example by a cut of scissors. The straw 10 is then in the state illustrated in FIG. 7. Next, the needle 44 having the female end piece 45 is connected to the straw.
    [0031] The hollow stem 39 of the needle 44 is then, for example, sunk into the septum of a container containing a dilution liquid (eg, water for injection) for concentrated vaccine solution (not shown). In order to empty the straw 10 according to the first embodiment of the emptying, a dump device (partially illustrated) is used which comprises two rollers 47 each oriented in the same direction and arranged next to each other. The emptying device is configured so that the rollers 47 gradually crush the tube 11 from its end 17 to the cap 10 12. The air bubble 43 is thus pushed in the same direction and in turn pushes the substance 21 which is successively introduced into the inner conduit 20 of the plug 12 and into the channel 40 of the needle 44 to be expelled from the needle 44, into the container containing the dilution liquid. The volume of the air bubble 43 is sufficient to fill the inner conduit 20 and the channel 40 when the rollers 47 are near the plug 12. Thus, there is no or very little substance 21 lost in the conduit 20 and in the channel 40. The emptying device comprising the rollers 47 is for example implemented by further providing a body and a rail mounted fixed on the body.
    [0032] The rollers 47 are slidably mounted along the rail, with the rollers 47 each oriented transversely to the direction of extension of the rail. The emptying device is configured to move the rollers 47 closer or closer to one another depending on where the two rollers 47 are on the rail.
    [0033] The emptying device further comprises an elastically erasable floor disposed under the rail. To empty the straw 10, the rollers 47 are initially positioned at a first end of the rail, access to the floor being thus cleared to allow the straw 10 to be disposed therein.
    [0034] The straw is then disposed on the floor, oriented in the same direction as the rail and located substantially between the respective paths of the two rollers 47, with the weld 41 of the straw facing the rollers 47. The needle 44 located at the other end of the straw is engaged in a conical housing formed in the body of the device, with the outer surface 5 of the female end abutting against the inner surface of the conical housing. The rollers 47 are then moved in the direction of the straw 10 and are positioned on either side of the weld 41 located near the end 17 of the straw. The rollers are then spaced from each other, separated by a distance slightly greater than the thickness of the weld 41 located between them. Once the weld 41 has been passed, the rollers 47 continue their course by approaching each other until the tube 11 of the straw 10 is crushed. The distance between the rollers is then approximately equal to twice 15 l. The rollers 47 then gradually crush the tube 11 as explained above. During its travel, the roller 47 closest to the floor (hereinafter the bottom roller) presses against an inclined surface of the floor, which biases the floor towards its erased position. The straw 10 is then no longer held by the floor but remains in the same position because it is held by the rollers 47. When the lower roll 47 reaches the end of the stroke, that is to say near the plug 12 of the straw, it is beyond the distal end of the floor which then returns to its initial position under the effect of the elastic member against which it had been erased. The distal end of the floor is then positioned behind the lower roller 47 and acts as a non-return stop for the two rollers 47.
    [0035] The fact that the two rollers 47 are prevented from moving back once close to the plug 12 prevents the tube 11 of the straw 10 from returning to its initial shape and thus limits the risks of re-suctioning the substance 21 ejected. We will now describe a second embodiment of emptying the flake 10 in support of Figures 10 and 11.
    [0036] The connection of the needle 44 to the straw 10 is effected as explained above. In contrast to the embodiment of the emptying illustrated in FIGS. 8 and 9, the weld 41 situated in the vicinity of the end 17 is removed by cutting an end portion flush with this weld 41.
    [0037] The fact that the cutting of the tube 11 is carried out flush with this weld 41 allows the air bubble 43 to keep almost the same volume before and after cutting. Rather than employing a dump device comprising two rollers 47, a device (partially illustrated) having a piston 52 is employed here. The piston 52 is moved to urge the air bubble 43 which then pushes the substance 21 at its expulsion out of the needle 44, in the same manner as in the embodiment illustrated in Figures 8 and 9. To clear the male end 29 to connect the needle end 20 45 of the needle 44, it is possible to cut the tube 11 using a pair of scissors 53 curved blades 54 (Figure 12) suitable for cooperating with the annular groove 30 of the plug 12, the annular groove 30 guiding the movement of the blades 54. Once the spigot 29 has been freed, it is still necessary to cut the annular wall 64 and remove the cap 33 in order to be able to connect the needle 44. Once the cap 33 has been removed, the flake 10 is in the same position. the state shown in Figure 13. It can then be emptied.
    [0038] We will now describe a second embodiment of the straw according to the invention in support of Figures 14 to 17.
    [0039] In general terms, for the elements similar to the embodiment of FIGS. 1 to 13, the same references have been used but the number 100 has been added. The internal diameter of the tube 111 is here of the order of 6 mm and the length of the tube 111 is of the order of 130 mm. The straw 110 here has a useful capacity of about 2 ml. The male end-piece 129 is identical to the male end-piece 29. The body 109 of the cap 112 is identical to the body 9 of the cap 12, except that it is of smaller dimensions in order to be able to cooperate with the tube 111. whose dimensions are smaller than those of the tube 11. The inner pipe 120 of the cap 112 is here completely frustoconical. The use of the straw 110 is identical to the use of the straw 10, except that, as the tube 111 is very close to the nozzle 129, the tube 111 is cut at the groove 130 to avoid that the tube 111 hinders the engagement of the tip 145 on the tip 129 (Figure 17). Referring to FIGS. 18 and 19, variants of the plug 12 or 112 will now be described. In general, for the elements similar to those of the plug 12, the same reference numerals have been used, but the number 200 the variant of Figure 18 and the number 300 for the variant of Figure 19. The plug 212 shown in Figure 18 is generally similar to the plug 112, except that the body 209 has a single 25 annular rib 222 and that this single annular rib 222 has a different profile than the ribs 122 or 22. While the outermost part of the ribs 22 or 122 is formed by a stop 65 or 165, the outermost part of the rib 222 is formed by a circular section surface of constant diameter 66. The diameter of the surface 66 corresponds to that of the inner surface of the tube of the straw. On either side of the surface 66, the rib 222 has an inclined surface, respectively 67 and 68.
    [0040] The surface 67 is turned towards the first end 219 of the cap 212 and is inclined towards the first end 219 and inwards. The inclined surface 68 is facing the second end 218 and is inclined towards the first end 218 and inwardly.
    [0041] The cap 312 illustrated in Fig. 19 is generally similar to the plug 112, except that the two annular ribs 122 are replaced by a single rib 322 having a large axial extension. In variants not shown, the body of the cap of the flake 10 has different non-return protrusions ribs 22, 122 or 322, but arranged differently from a rib, for example in the form of a plurality of tabs. In other non-illustrated variants: the plug 12, 112, 212 or 312 is not entirely disposed within the tube of the straw at a predetermined distance from its first end, but protrudes outwardly beyond its first end; - The cap is made fixed relative to the tube other than by mechanical cooperation of surfaces, for example by providing a securing by gluing or welding; The tube of the straw is made of several plastics, for example by coextrusion; - The plug 12 is made of several materials, for example a relatively flexible material for the appendage and a central portion of the body while the periphery of the body is relatively rigid material; The stopper comprises a gas-permeable and liquid-impermeable part, to allow conventional filling, for example the cover is replaced by a tubular part associated with a gas-permeable and liquid-impervious element such as a conventional tripartite stopper; ; The appendix is permeable, for example it does not comprise a lid; The body of the stopper comprises more than two annular ribs, for example three or four ribs; the welds made to close the end portions of the tube of the straw are arranged at a certain distance from the ends, for example several millimeters; and / or - the contact elements of the device for emptying the tube of the straw are different from the rollers such as 47, for example two supporting fingers or an assembly formed by a fixed base and a movable support finger.
    [0042] Numerous other variations are possible depending on circumstances, and it is recalled in this respect that the invention is not limited to the examples described and shown.
    权利要求:
    Claims (17)
    [0001]
    REVENDICATIONS1. Flake for preserving a predetermined dose of liquid-based substance, comprising a tube (11, 111) extending between a first end (16, 116) and a second end (17, 117) and having a plug (12, 112, 212) 312) disposed in the tube (11, 111) adjacent its first end (16, 116) and extending between a first end (19, 119, 219, 319) facing the first end (16, 116), ) of the tube (11, 111) and a second end (18, 118, 218, 318) facing the second end (17, 117) of the tube (11, 111), characterized in that said plug (12, 112, 212, 312): - is fixed with respect to the tube (11, 111); - has a male connector (29, 129) extending between a first end (60, 160) facing the first end (16, 116) of the tube (11, 111) and a second end (61, 161) facing the second end (17,117) of the tube (11,111) having a normalized frustoconical outer surface (14,114) increasing in diameter the first end (60,160) of the tip (29,129) to the second end (61,161) of the tip (29,129) configured for a syringe needle (44,144) having a tapered inner surface (46) female connector tip (45,145) standard can be connected to said plug (12, 112, 212, 312) by engaging the needle connector (45, 145) of the needle on the male connector (29, 129) of the plug (12, 112, 212, 312) with the internal frustoconical surface (46) of the socket (45, 145) in contact with the outer frustoconical surface (14, 114) of the spigot (29, 12 9); and - has an inner conduit (20, 120) extending between the first end (60, 160) of the hub (29, 129) and the second end (18, 118, 218, 318) of the plug (12, 112, 212, 312).
    [0002]
    2. Sequins according to claim 1, characterized in that, in an initial state before use, the first end (19, 119, 219, 319) of the plug (12, 112, 212, 312) is located in the tube (11 , 111) at a predetermined distance from the first end (16, 116) of the tube (11, 111) for welding the tube (11, 111) between the first end (19, 119, 219, 319) of the plug (12, 112, 212, 312) and the first end (16, 116) of the tube (11, 111). 5
    [0003]
    3. straw according to any one of claims 1 or 2, characterized in that, in an initial state before use, the plug (12, 112, 212, 312) comprises at its first end (19, 119, 219, 319 ) a cover (33, 133) to be removed closing said inner conduit (20) of the plug (12, 112, 212, 312). 10
    [0004]
    4. straw according to claim 3, characterized in that an annular wall (64, 164) is disposed between the cap (33, 133) and the male end (29, 129), the inner duct (20, 120). ) of the plug (12, 112, 212, 312) extending beyond the first end (60, 160) of the spigot (29, 129) in the annular wall (64, 164) to the cover (33, 133) which closes it, the outer surface of the annular wall (64, 164) being recessed vis-à-vis the outer surface (14, 114) of the male end (29, 129 ).
    [0005]
    5. straw according to any one of claims 1 to 4, characterized in that the plug (12, 112, 212, 312) comprises a body (9, 109, 209, 309) secured to the tube (11, 111) and an appendage (63, 163, 263, 363) protruding from said body (9, 109, 209, 309) secured to the tube (11, 111) only through the body (9, 109, 209, 309), which appendix (63, 163, 263, 363) includes said spigot (29, 129) and extends to the first end (19, 119, 219, 319) of the plug (12, 112, 212, 312).
    [0006]
    6. straw according to claim 5, characterized in that the body 25 (9, 109, 209, 309) of the plug (12, 112, 212, 312) and the tube (11, 111) are subject independently of a contact plug (12, 112, 212, 312) with said liquid-based substance (21).
    [0007]
    7. straw according to any one of claims 5 or 6, characterized in that the body (9, 109, 209, 309) is rigid at least peripherally and comprises an outer surface (28, 128) having anti protrusions -return (22, 122, 322) oriented to allow for forced sliding of the plug (12, 112, 312) towards the tube (11, 111) of the first end (16, 3036954 116) towards the second end (17, 117) and to resist sliding of the plug (12, 112, 312) with respect to the tube (11, 111) towards the first end (16, 116) of the tube (11, 111).
    [0008]
    8. straw according to any one of claims 5 to 7, characterized in that the body (9, 109, 209, 309) is rigid at least peripherally and has an outer surface (28, 128) having at least one annular rib (22, 122, 322) having a straight surface (24, 124) facing the first end (16, 116) of the tube (11, 111) and an inclined surface (25, 125) facing the second end ( 17, 117) of the tube (11, 111), the inclined surface (25, 125) being inclined inwards and towards the second end (17, 117) of the tube (11, 111).
    [0009]
    9. straw according to any one of claims 5 to 8, characterized in that the body (9, 109) is rigid at least peripherally and has an outer surface (28, 128) having at least two annular ribs (22, 128). , 122) away from each other.
    [0010]
    10. Sequins according to any one of claims 5 to 9, characterized in that the body (9, 109, 209, 309) has on its outer surface (28, 128) an annular groove (30, 130, 230, 330 ) near the appendix (63, 163, 263, 363). 20
    [0011]
    11. straw according to any one of claims 1 to 10, characterized in that said male connector end (29, 129) is a male luer tip.
    [0012]
    The straw according to any one of claims 1 to 11, characterized in that said plug (12, 112, 212, 312) is entirely made of gas and liquid impervious material independently of a contact of the plug (12, 112, 212, 312) with said liquid-based substance (21).
    [0013]
    13. Flake according to any one of claims 1 to 12, characterized in that said plug (12, 112, 212, 312) is entirely of rigid plastic material molded in one piece. 30
    [0014]
    14. Device for injecting a liquid-based substance comprising a straw (10, 110) according to one of the preceding claims and a syringe needle (44, 144) having a female connection end (45, 3036954 26 145 ) with a frustoconical inner surface (46) engaged on the male connecting piece (29, 129) of the plug (12, 112, 212, 312) of said straw (10, 110).
    [0015]
    A method of emptying a straw according to any one of claims 1 to 13, comprising a dose of liquid-based substance (21) disposed between the second end (18, 118, 218, 318) of the plug (12, 112 212, 312) and the second end (17, 117) of the tube (11, 111), comprising the step of pushing the dose of liquid-based substance (21) towards the first end (16, 116) of the tube ( 11, 111) after connecting the socket (45, 145) of a syringe needle (44, 144) to the plug (29, 129) of the plug (12, 112, 212, 312).
    [0016]
    16. The method of claim 15, characterized in that the step of pushing the dose of liquid-based substance (21) is implemented with the second end (17, 117) of the tube (11, 111) which remains closed while the tube (11, 111) is progressively crushed from the second end (17, 117) of the tube (11, 111) to the plug (12, 112, 212, 312).
    [0017]
    17. The method of claim 15, characterized in that the step of pushing the dose of liquid-based substance (21) is implemented with the second end (17, 117) of the tube (11, 111) which is open. , by means of a piston (52) introduced by this end (17, 117) which is displaced towards the plug (12, 112, 212, 312).
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    同族专利:
    公开号 | 公开日
    FR3036954B1|2017-07-14|
    CN107708608A|2018-02-16|
    EP3302351A1|2018-04-11|
    US20180110604A1|2018-04-26|
    EP3302351B1|2019-03-20|
    US10987206B2|2021-04-27|
    BR112017025219A2|2018-08-07|
    WO2016193630A1|2016-12-08|
    CN107708608B|2019-08-13|
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    法律状态:
    2016-06-29| PLFP| Fee payment|Year of fee payment: 2 |
    2016-12-09| PLSC| Search report ready|Effective date: 20161209 |
    2017-06-29| PLFP| Fee payment|Year of fee payment: 3 |
    2018-06-28| PLFP| Fee payment|Year of fee payment: 4 |
    2019-06-26| PLFP| Fee payment|Year of fee payment: 5 |
    2021-03-12| ST| Notification of lapse|Effective date: 20210205 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1555026A|FR3036954B1|2015-06-03|2015-06-03|STRAW FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, AND INJECTION DEVICE AND METHOD FOR CARRYING OUT THE SAME|FR1555026A| FR3036954B1|2015-06-03|2015-06-03|STRAW FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, AND INJECTION DEVICE AND METHOD FOR CARRYING OUT THE SAME|
    CN201680031973.9A| CN107708608B|2015-06-03|2016-06-02|Predetermined close liquid-based substance saves tubule and injection device and method using tubule|
    PCT/FR2016/051321| WO2016193630A1|2015-06-03|2016-06-02|Straw for keeping a predetermined dose of liquid-based substance, and injection device and method implementing same|
    BR112017025219A| BR112017025219A2|2015-06-03|2016-06-02|straw to conserve a predetermined dose of liquid-based substance, and injection device and method implanting the same|
    EP16738477.5A| EP3302351B1|2015-06-03|2016-06-02|Straw for keeping a predetermined dose of liquid-based substance, and injection device and method implementing same|
    US15/578,804| US10987206B2|2015-06-03|2016-06-02|Straw for the preservation of a predetermined dose of liquid-based substance, as well as a method and injection device that employ it|
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